MET

n-ethyl-n-methyltryptamine (also known as methylethyltryptamine, and met) is a lesser-known novel psychedelic substance of the tryptamine class that produces powerful and short-lived psychedelic effects when administered. it is structurally related to dmt and is similarly unique among psychedelics due to its short-lived effects, rapid onset and progressive stages.

the fumarate salt has been reported as being active via smoking/vaporization at 15-65 mg and orally at 80-110 mg. when smoked or vaporized it has been reported to produce effects similar to those of dmt with some distinct stylistic variations which include a more grounded headspace, stimulating physical effects, and reduced subjective intensity.

very little data exists about the pharmacological properties, metabolism, and toxicity of met, and it has a very brief history of human usage. today, it is either used recreationally or as an entheogenic substance and has been exclusively distributed by online research chemical vendors since mid-2016. due to its unstudied properties and effects, it is highly advised to approach this novel psychedelic substance with the proper precautions and harm reduction practices if choosing to use it.

chemistry

met, or n-ethyl-n-methyltryptamine, is a synthetic indole molecule of the tryptamine class. tryptamines share a core structure that comprises a bicyclic indole heterocycle attached at r₃ to an amino group via an ethyl side chain. unlike dmt, which contains two methyl groups, met contains groups of one methyl and one ethyl carbon chains bound to the terminal amine r_n of its tryptamine backbone.

pharmacology

as with most psychedelic tryptamines, met is thought to act principally as a 5-ht_2a partial agonist. the psychedelic effects are believed to come from met’s binding efficacy at the 5-ht_2a receptors. however, the role of these interactions and how they result in the psychedelic experience continue to remain elusive.