Diclazepam

diclazepam (also known as chlorodiazepam) is a synthetic depressant substance of the benzodiazepine chemical class that produces effects similar to diazepam, such as anxiety suppression, disinhibition, anticonvulsant, hypnotic, muscle relaxing, and amnesia when administered. it was first synthesized by leo sternbach and his team at hoffman-la roche in 1960. in animal models it has a potency of approximately ten times that of diazepam, of which it is a structural analog.

diclazepam is not currently marketed as a medication, but rather sold online as a research chemical. its potency has not been systematically tested in humans, but its closest relatives and two main metabolites are lormetazepam with a potency value of x10-12 of delorazepam which is roughly x10 the potency of diazepam.

users should note that the sudden discontinuation of benzodiazepines can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death. it is highly recommended to taper one’s dose by gradually lowering the amount taken each day over a prolonged period of time rather than stopping use abruptly, as this can lead to crippling, potentially life-threatening withdrawal symptoms.

chemistry

composition

diclazepam is a drug of the benzodiazepine class. benzodiazepine drugs contain a benzene ring fused to a diazepine ring, which is a seven-membered ring with the two nitrogen constituents located at r₁ and r₄. at r₁, diclazepam is substituted with methyl group. further, the benzodiazepine ring is bonded at r₅ to a 2-chlorinated phenyl ring. r₇ of the benzyl ring is also substituted with a chlorine group. diclazepam also contains an oxygen group double bonded to r₂ of its diazepine ring to form a ketone. this oxygen substitution at r₂ is shared with other benzodiazepine drugs with the suffix -azepam.

pharmacology

benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (gaba) by acting on its receptors. as this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of diclazepam on the nervous system.

the anticonvulsant properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.