3-MeO-PCE

3-methoxyeticyclidine (also known as methoxieticyclidine and 3-meo-pce) is a novel dissociative substance of the arylcyclohexylamine class that produces dissociative and hallucinogenic effects when administered. it is a structural analog of pce.

3-meo-pce began to gain popularity in 2010 and is sold on the online grey area research chemical market as a legal alternative to pcp or ketamine.

very little data exists about the pharmacological properties, metabolism, and toxicity of 3-meo-pce, and it has a very brief history of human usage. it is strongly recommended that one use harm reduction practices if using this substance.

chemistry

3-meo-pce, or n-ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine, is classed as an arylcyclohexylamine drug. ayrlcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 3-meo-pce contains a phenyl ring with a methoxy (ch₃-o-) substituent at r₃ bonded to a cyclohexane ring. bound to the same carbon (r₁) of the cyclohexanone ring is an amino ethyl chain -nch₂ch₃. 3-meo-pce, like mxe, contains an amino ethyl chain rather than the amino methyl chain found in dck and ketamine. 3-meo-pce is analogous to mxe, but lacks an r₂ substituted ketone. it is also homologous to 3-meo-pcp but lacks the additional carbons to complete a piperidine ring.

pharmacology

3-meo-pce acts principally as an nmda receptor antagonist. nmda receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. dissociatives close the nmda receptors by blocking them. this disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”

3-meo-pce has ki values of 61 nm for the nmda receptor, 743 nm for the dopamine transporter, 2097 nm for the histamine h2 receptor, 964 nm for the alpha-2a adrenergic receptor, 115 nm for the serotonin transporter, 4519 nm for the σ1 receptor and 525 nm for the σ2 receptor.